4.2 Article

The alcohol-preferring (P) and high-alcohol-drinking (HAD) rats - Animal models of alcoholism

期刊

ALCOHOL
卷 48, 期 3, 页码 209-215

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.alcohol.2013.09.044

关键词

Alcohol-preferring (P) rat; High-alcohol-drinking (HAD) rat; Animal model of alcoholism; Binge drinking; Alcohol-seeking behavior

资金

  1. NIAAA [AA07611, AA010721, AA012262, AA011261, AA010256, AA019366]

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The objective of this article is to review the literature on the utility of using the selectively bred alcohol preferring (P) and high-alcohol-drinking (HAD) lines of rats in studies examining high alcohol drinking in adults and adolescents, craving-like behavior, and the co-abuse of alcohol with other drugs. The P line of rats meets all of the originally proposed criteria for a suitable animal model of alcoholism. In addition, the P rat exhibits high alcohol-seeking behavior, demonstrates an alcohol deprivation effect (ADE) under relapse drinking conditions, consumes amounts of ethanol during adolescence equivalent to those consumed in adulthood, and co-abuses ethanol and nicotine. The P line also exhibits excessive binge-like alcohol drinking, attaining blood alcohol concentrations (BACs) of 200 mg% on a daily basis. The HAD replicate lines of rats have not been as extensively studied as the P rats. The HAD1,2 rats satisfy several of the criteria for an animal model of alcoholism, e.g., these rats will voluntarily consume ethanol in a free choice situation to produce BACs between 50 and 200 mg%. The HAD 1,2 rats also exhibit an ADE under repeated relapse conditions, and will demonstrate similar levels of ethanol intake during adolescence as seen in adults. Overall, the P and HAD1,2 rats have characteristics attributed to an early onset alcoholic, and can be used to study various aspects of alcohol use disorders. (C) 2014 Elsevier Inc. All rights reserved.

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