期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 74, 期 -, 页码 68-75出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2014.11.043
关键词
Porphyra yezoensis; Antioxidant activity; Anti-inflammatory activity
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- Nagasaki University Major Research Project (Research Initiative for Adaptation to Future Ocean Change)
- Jeju Center at the Korea Basic Science Institute of Korea [C34290]
- National Research Council of Science & Technology (NST), Republic of Korea [C34290] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Grants-in-Aid for Scientific Research [15K07580, 14J00356] Funding Source: KAKEN
We found that discolored waste nod with no commercial value, contains much higher level of porphyran than normal nod that is a sheeted food stuff prepared from P. yezoensis used in sushi. Chemical analyses revealed that mean molecular mass of the porphyran prepared from discolored nori (dc-porphyran) was much lower than that of the porphyran from normal nori (n-porphyran). Dc-porphyran showed slightly greater scavenging activity toward superoxide anion and hydroxyl radical than n-porphyran. Dc-porphyran inhibited nitric oxide (NO) production in LPS-stimulated RAW264.7 cells through preventing the expression of inducible NO synthase, whereas no such activity was observed in n-porphyran. Since acid-hydrolyzed n-porphyran showed the inhibitory activity on NO production from LPS-stimulated RAW264.7 cells, the molecular size of porphyran was suggested to be a critical factor for the activity. Dc-porphyran was separated into 4 fractions (F1-F4) on DEAE-chromatography, and F1 showed the highest inhibitory effect on NO production from LPS-stimulated RAW264.7 cells. Our results indicate that discolored waste nori useful as a source of porphyran with even better bioactivities than porphyran from normal nori. (C) 2014 Elsevier B.V. All rights reserved.
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