期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 72, 期 -, 页码 706-710出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2014.09.021
关键词
Methyl cellulose; Molecular weight effect; Gelation behavior; Rheological property; In vitro drug release
资金
- CSIR [02 (0077)/12/EMR-II]
- University Grant Commission, Govt. of India
The effect of weight average molecular weight (M-w) of methyl cellulose (MC) on the gelation behavior of Poloxamer 407 (PM) and in vitro release of Ketorolac Tromethamine (KT) from different ophthalmic formulations based on PM is examined. A drop of gelation temperature of PM is observed using MC of various M-w by test tube tilting method, UV-vis spectroscopy, viscometry and rheometry. It is also observed that the viscosity and gel strength of all the formulations are increased with the increase in M-w of MC. PM with highest M-w of MC provides best drug release property among all the formulations. It is evident from this investigation that there is a distinct effect of M-w of MC on the gelation behavior of PM as well as on the drug release profile of KT from PM-MC based ophthalmic formulations. (C) 2014 Elsevier B.V. All rights reserved.
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