期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 26, 期 6, 页码 717-723出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/aid.2009.0254
关键词
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资金
- Bill and Melinda Gates Foundation [38631]
- NIH [DPOD004631, R01A1084119]
- NSF [DGE-0333389]
The diversity of HIV-1 is a confounding problem for vaccine design, as the human immune response appears to favor poor or strain-specific responses to any given HIV-1 virus strain. A significant portion of this diversity is manifested as sequence variability in the loops of HIV-1's surface envelope glycoprotein. Here we show that the most variable sequence positions in the third variable (V3) loop crown cluster to a small zone on the surface of one face of the V3 loop beta-hairpin conformation. These results provide a novel visualization of the gp120 V3 loop, specifically demonstrating a surprising preponderance of conserved three-dimensional structure in a highly sequence-variable region. From a structural point of view, there appears to be less diversity in this region of the HIV-1 principle neutralizing domain than previously appreciated.
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