期刊
AIDS
卷 27, 期 9, 页码 1513-1516出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e32835faa72
关键词
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资金
- European Society of Pediatric Infectious Diseases (ESPID)
- Spanish Ministry of Science and Innovation
- Instituto de Salud Carlos III, Spanish Health Ministry [RD06/0006/0035]
- Fundacion para la Investigacion y Prevencion del SIDA en Espana (FIPSE) [361910-10]
We explored the associations of the CD4/CD8 ratio with markers of immunoactivation, immunosenescence and T-cell subsets, in 37 vertically HIV-infected children and adolescents. CD4/CD8 ratio inversion was associated with higher frequencies of activated, senescent and activated/exhausted CD4(+) and CD8(+) T-cells, and a skewed T-cell phenotype from naive toward effector memory which persisted after the multivariate analysis. Thus, the CD4/CD8 ratio may identify patients with higher immunoactivation despite ART.
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