期刊
AIDS
卷 27, 期 15, 页码 2365-2373出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e3283635232
关键词
AIDS; Burkitt lymphoma; diffuse large B-cell lymphoma; HIV; Hodgkin lymphoma; lymphoma; non-Hodgkin lymphoma
资金
- CNICS, an NIH made possible by the National Institute of Allergy and Infectious Diseases [R24 AI067039]
- University of North Carolina CFAR, an NIH [P30 AI50410]
- University of Alabama at Birmingham CFAR [P30 AI027767]
- Case Western Reserve University CFAR [P30 AI36219]
- UNC Lineberger Comprehensive Cancer Center Developmental Research Award
- Fogarty International Center of the NIH through the Fogarty Global Health Fellows Program [1R25TW009340-01]
- International Scientist Development Award [1K01TW009488-01]
- AIDS Malignancy Consortium Fellowship Award
Objective:To examine the association between early HIV viremia and mortality after HIV-associated lymphoma.Design:Multicenter observational cohort study.Setting:Center for AIDS Research Network of Integrated Clinical Systems cohort.Participants:HIV-infected patients with lymphoma diagnosed between 1996 and 2011, who were alive 6 months after lymphoma diagnosis and with at least two HIV RNA values during the 6 months after lymphoma diagnosis.Exposure:Cumulative HIV viremia during the 6 months after lymphoma diagnosis, expressed as viremia copy-6-months.Main outcome measure:All-cause mortality between 6 months and 5 years after lymphoma diagnosis.Results:Of 224 included patients, 183 (82%) had non-Hodgkin lymphoma (NHL) and 41 (18%) had Hodgkin lymphoma. At lymphoma diagnosis, 105 (47%) patients were on antiretroviral therapy (ART), median CD4(+) cell count was 148cells/l (interquartile range 54-322), and 33% had suppressed HIV RNA (<400copies/ml). In adjusted analyses, mortality was associated with older age [adjusted hazard ratio (AHR) 1.37 per decade increase, 95% CI 1.03-1.83], lymphoma occurrence on ART (AHR 1.63, 95% CI 1.02-2.63), lower CD4(+) cell count (AHR 0.75 per 100cells/l increase, 95% CI 0.64-0.89), and higher early cumulative viremia (AHR 1.35 per log(10)copiesx6-months/ml, 95% CI 1.11-1.65). The detrimental effect of early cumulative viremia was consistent across patient groups defined by ART status, CD4(+) cell count, and histology.Conclusion:Exposure to each additional 1-unit log(10) in HIV RNA throughout the 6 months after lymphoma diagnosis was associated with a 35% increase in subsequent mortality. These results suggest that early and effective ART during chemotherapy may improve survival.
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