期刊
AIDS
卷 27, 期 15, 页码 2375-2384出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e328363bf7f
关键词
accelerated ageing; Africa; biomarkers of ageing; CDKN2A; HIV; telomeres
资金
- Wellcome Trust [090354/Z/09/Z]
- Wellcome Trust, London [088590]
- IEDEAA, International Epidemiologic Database to Evaluate AIDS [5U01AI069924-02]
- CEPAC Cost-Effectiveness of Preventing AIDS Complications 5 [R01AI058736-02]
- MRC [G0700837] Funding Source: UKRI
- Medical Research Council [G0700837] Funding Source: researchfish
- Wellcome Trust [090354/Z/09/Z] Funding Source: Wellcome Trust
Objectives:Little is known about the impact of HIV infection on biological ageing in sub-Saharan Africa. The study aimed to assess biological ageing in South African HIV-infected adults and HIV-seronegative individuals using two validated biomarkers, telomere length and CDKN2A expression (a mediator of cellular senescence).Design:A case-control study.Methods:Two hundred and thirty-six HIV-infected adults aged at least 30 years and 250 age and sex frequency matched HIV-seronegative individuals were recruited from clinics in township communities in Cape Town. Biological ageing was evaluated by measurement of telomere length and CDKN2A expression in peripheral blood leukocytes.Results:The median ages of the HIV-infected and HIV-seronegative participants were 39 and 40 years, respectively. Among HIV-infected participants, 87.1% were receiving antiretroviral therapy (ART), their median CD4(+) cell count was 468cells/l and 84.3% had undetectable viral load. Both biomarkers were validated against chronological age in HIV-seronegative individuals. Telomere length was significantly shorter in HIV-infected individuals than in HIV-seronegative individuals (mean relative T/S ratio SE:0.91 +/- 0.007 vs. 1.07 +/- 0.008, P<0.0001). CD2NKA expression was higher in HIV-infected participants than in HIV-seronegative individuals (mean expression: 0.45 +/- 0.02 vs. 0.36 +/- 0.03, P=0.003). Socioeconomic factors were not associated with biological ageing in HIV-infected participants. However, in participants on ART with undetectable viral load, biomarker levels indicated greater biological ageing in those with lower current CD4(+) cell counts.Conclusion:Telomere length and CDKN2A expression were both consistent with increased biological ageing in HIV-infected individuals. Prospective studies of the impact of HIV on biological ageing in sub-Saharan Africa are warranted.
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