Epicardial adipose tissue is an independent marker of cardiovascular risk in HIV-infected patients

Background: Epicardial adipose tissue (EAT) is increased in HIV-infected patients. The aim of this study was to evaluate the association between EAT and coronary artery calcium (CAC) a marker of atherosclerosis; furthermore, we investigated the association of EAT with HIV infection, antiretroviral therapy (ART), and lipodystrophy. Methods: This was a cross-sectional study of 876 consecutive HIV-infected ART experienced patients. Patients underwent CAC imaging with multidetector computed tomography (CT) for atherosclerosis screening and risk of cardiovascular events (CAC score > 100); EAT was measured in the same CT images. Factors independently associated with EAT were explored in a multivariable backward stepwise linear regression analysis. Multivariable logistic regression was used to evaluate the association of EAT and CAC score greater than 100. Results: Patients' mean age was 47.2 +/- 8 years, 68% were men. EAT was associated with central fat accumulation and mixed lipodystrophy phenotypes. Factors independently associated with EAT were: age [beta = 0.6, confidence interval (CI) 0.2-1.0], male sex (beta = 6.6, CI 0.5-12.7), visceral adipose tissue (beta = 0.12, CI 0.08-0.17), waist circumference (beta = 0.7, CI 0.04-1.3), current CD4(+) (beta = 0.6, CI 0.1-1.2, per 50 cells), total cholesterol (beta = 0.1, CI 0.02-0.15), and cumulative exposure to ART (months) (beta = 0.05, CI 0.00-0.11). EAT (per 10 cm(3)) was associated with CAC greater than 100 (odds ratio = 1.10, CI 1.02-1.19) after adjustment for age, male sex, and diabetes. Conclusion: We showed an association between EAT and central fat accumulation and mixed form lipodystrophy phenotypes as well as traditional risk factors for atherosclerosis. EAT may be a useful marker of cardiovascular risk as shown by its association with CAC greater than 100. (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins