期刊
AIDS
卷 24, 期 9, 页码 1377-1380出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/QAD.0b013e3283396024
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资金
- NCRR NIH HHS [M01 RR00750, M01 RR000750] Funding Source: Medline
- NHLBI NIH HHS [K23 HL073682, R01 HL095149, R01 HL072711, R01 HL095149-01, K23 HL073682-05, R01 HL072711-01] Funding Source: Medline
We performed a single-arm, open-label pilot trial of the anti-inflammatory drug pentoxifylline to reduce systemic inflammation and improve endothelial function, measured by flow-mediated dilation of the brachial artery, in HIV-infected patients not requiring antiretroviral therapy. Pentoxifylline significantly reduced circulating levels of vascular cell adhesion molecule-1 and interferongamma-induced protein and significantly improved endothelial function during the 8-week trial. Pentoxifylline may reverse HIV-related endothelial dysfunction by directly inhibiting the endothelial leukocyte adhesion pathway.
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