期刊
ANNALS OF HEPATOLOGY
卷 8, 期 3, 页码 258-266出版社
ELSEVIER ESPANA
DOI: 10.1016/S1665-2681(19)31777-6
关键词
Ayurvedic herbal products; Hepatotoxicity; Causality assessment
The case of a 64 year old female patient is presented who has treated herself for 9 months with various Indian Ayurvedic herbal products for her vitiligo and experienced a causally related severe hepatotoxicity (ALT, 601 U/L; AST, 663 U/L; Bilirubin, 5.0 mg/dL). After discontinuation, a rapid improvement was observed. Causality assessment with the updated CIOMS (Council for International Organizations of Medical Sciences) scale showed a probable causality (+8 points) for Bakuchi tablets containing extracts from Psora-Lea corylifolia leaves with psoralens as ingredients, as the primary candidate causing the hepatotoxic reaction. The degree of probability was tower with +6 points for other used herbs: Khadin tablets containing extracts from Acacia catechu Leaves; Brahmi tablets containing Eclipta alba or Bacopa monnieri; and Us-heer tea prepared from Vetivexia zizaniodis. The case is the first report of Indian Ayurvedic herbal products being potentially hepatotoxic in analogy to some other herbs.
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