期刊
AICHE JOURNAL
卷 54, 期 11, 页码 2979-2989出版社
WILEY
DOI: 10.1002/aic.11600
关键词
nanoparticles; pH-sensitive; self-assembly; polymer brush; drug delivery
资金
- American Cancer Society [RSG-06-118-01-CDD]
- National Science Foundation [DMR-0705298]
- National Institutes of Health [RR-016474]
polymer nanoparticles are extensively explored as drug carriers but they generally have issues of premature burst drug release. slow cellular uptake, and retention in acidic intracellular Compartments. Herein, we report multifunctioning three-layered nanoparticles (3LNPs) that can overcome these problems. The 3LNPs have a poly(epsilon-caprolactone) (PCL) core, a pH-responsive poly[2-(N,N-diethylamino)ethyl methacrylate] (P-DEA) middle layer and a polyethylene glycol (PEG) outer layer. The pH-responsive PDEA layer is insoluble at pH above 7 but becomes positively charged and soluble via protonation on at pH lower than 6.5. Thus, this layer has three functions: it covers on the PCL core inhibiting the premature burst drug release at the physiological pH, becomes positively charged and thus promotes endocytosis for fast cellular internalization in the acidic interstitium of solid tumors, and is highly positively charged in lysosomes to disrupt the lysosomal membrane and release the nanoparticle into the cytosol. The multifunctioning nanoparticles are an efficient carrier for cancer cytosolic drug delivery. (C) 2008 American Institute of Chemical Engineers AIChE J, 54: 2979-2989, 2008
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