期刊
EMERGING INFECTIOUS DISEASES
卷 15, 期 8, 页码 1214-1221出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid1508.081218
关键词
-
资金
- National Spanish [RTA2006-00091, AGL2005-03066]
- UK FSA [M03043]
- European Union [QLRT-2001-01309, FP6-2004-FOOD3-023183, CT2004-50657]
- Alssan Program
- Instituto Nacional de Investigacion y Tecnoloigia Agraria y Alimentaria
How susceptible pigs are to infection with sheep prions is unknown. We show, through transmission experiments in transgenic mice expressing porcine prion protein (PrP), that the susceptibility of this mouse model to bovine spongiform encephalopathy (BSE) can be enhanced after its passage in ARQ sheep, indicating that the pathogenicity of the BSE agent is modified after passage in sheep. Transgenic mice expressing porcine PrP were, nevertheless, completely resistant to infection with a broad panel of classical scrapie isolates from different sheep PrP genotypes and with different biochemical characteristics. The atypical (Nor98 like) isolate (SC-PS152) was the only scrapie isolate capable of transmission in these mice, although with a marked transmission barrier. Unexpectedly, the atypical scrapie agent appeared to undergo a strain phenotype shift upon transmission to porcine-PrP transgenic mice and acquired new strain properties, suggesting that atypical scrapie agent may exhibit different phenotypes depending on the host cellular PrP or other genetic factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据