期刊
AGING-US
卷 5, 期 9, 页码 662-681出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100595
关键词
dilp2; lifespan; intestinal barrier; insulin/insulin-like growth factor signaling; mitochondria
资金
- National Institute on Aging [R01 AG037514, R01 AG040288, R01 AG028092]
- Ellison Medical Foundation
- Eureka fellowship
- National Institutes of Health/National Institute of General Medical Sciences [NIH MARC T34 GM008563]
- National Science Foundation
- Ellison Medical Foundation New Scholar in Aging
A functional decline in tissue stem cells and mitochondrial dysfunction have each been linked to aging and multiple aging-associated pathologies. However, the interplay between energy homeostasis, stem cells, and organismal aging remains poorly understood. Here, we report that expression of the single-subunit yeast alternative NADH dehydrogenase, ndi1, in Drosophila intestinal stem and progenitor cells delays the onset of multiple markers of intestinal aging and extends lifespan. In addition, expression of ndi1 in the intestine increases feeding behavior and results in organismal weight gain. Consistent with increased nutrient uptake, flies expressing ndi1 in the digestive tract display a systemic reduction in the activity of AMP-activated protein kinase (AMPK), a key cellular energy sensor. Together, these results demonstrate that ndi1 expression in the intestinal epithelium is an effective strategy to delay tissue and organismal aging.
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