期刊
AGING-US
卷 4, 期 3, 页码 176-186出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100446
关键词
adult neurogenesis; neural stem cells; aging; regenerative therapies
资金
- DFG
- Medical Faculty of the Technical University Dresden
- Max Planck Institute of Molecular Cell Biology and Genetics
- DFG-Collaborative Research Center [SFB655]
Several studies suggest that an increase in adult neurogenesis has beneficial effects on emotional behavior and cognitive performance including learning and memory. The observation that aging has a negative effect on the proliferation of neural stem cells has prompted several laboratories to investigate new systems to artificially increase neurogenesis in senescent animals as a means to compensate for age-related cognitive decline. In this review we will discuss the systemic, cellular, and molecular changes induced by aging and affecting the neurogenic niche at the level of neural stem cell proliferation, their fate change, neuronal survival, and subsequent integration in the neuronal circuitry. Particular attention will be given to those manipulations that increase neurogenesis in the aged brain as a potential avenue towards therapy.
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