期刊
AGING-US
卷 3, 期 8, 页码 716-732出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100361
关键词
Polyamines; Aging; Age-related diseases; Cancer; Autophagy; Acetylation
资金
- Austrian Science Fund FWF [LIPOTOX, P23490]
- European Commission
- Austrian Science Fund (FWF) [P23490] Funding Source: Austrian Science Fund (FWF)
Polyamines are polycations that interact with negatively charged molecules such as DNA, RNA and proteins. They play multiple roles in cell growth, survival and proliferation. Changes in polyamine levels have been associated with aging and diseases. Their levels decline continuously with age and polyamine (spermidine or high-polyamine diet) supplementation increases life span in model organisms. Polyamines have also been involved in stress resistance. On the other hand, polyamines are increased in cancer cells and are a target for potential chemotherapeutic agents. In this review, we bring together these various results and draw a picture of the state of our knowledge on the roles of polyamines in aging, stress and diseases.
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