期刊
AGING-US
卷 2, 期 3, 页码 122-128出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100130
关键词
Circadian clock; cell cycle; hair growth cycle; aging; hair loss
资金
- NIH [AR44882]
- California Breast Cancer Research Fellowship [14GB-0163]
- NATIONAL CANCER INSTITUTE [P30CA062203] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR044882] Funding Source: NIH RePORTER
Hair follicles undergo continuous cycles of growth, involution and rest. This process, referred to as the hair growth cycle, has a periodicity of weeks to months. At the same time, skin and hair follicles harbor a functional circadian clock that regulates gene expression with a periodicity of approximately twenty four hours. In our recent study we found that circadian clock genes play a role in regulation of the hair growth cycle during synchronized hair follicle cycling, uncovering an unexpected connection between these two timing systems within skin. This work, therefore, indicates a role for circadian clock genes in a cyclical process of much longer periodicity than twenty four hours.
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