期刊
AGING-US
卷 1, 期 7, 页码 637-651出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.100054
关键词
Drosophila; p38b MAPK; aging; oxidative stress; intestinal stem cell; gut; PVR signaling; Delta/Notch pathway; proliferation; differentiation
资金
- Korea Research Foundation [KRF-2007-313-C00532]
- Pusan National University
- National Research Foundation of Korea [2007-313-C00532] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
It is important to understand how age-related changes in intestinal stem cells (ISCs) may contribute to age-associated intestinal diseases, including cancer. Drosophila midgut is an excellent model system for the study of ISC proliferation and differentiation. Recently, age-related changes in the Drosophila midgut have been shown to include an increase in ISC proliferation and accumulation of mis-differentiated ISC daughter cells. Here, we show that the p38b MAPK pathway contributes to the age-related changes in ISC and progenitor cells in Drosophila. D-p38b MAPK is required for an age-related increase of ISC proliferation. In addition, this pathway is involved in age and oxidative stress-associated mis-differentiation of enterocytes and upregulation of Delta, a Notch receptor ligand. Furthermore, we also show that D-p38b acts downstream of PVF2/PVR signaling in these age-related changes. Taken together, our findings suggest that p38 MAPK plays a crucial role in the balance between ISC proliferation and proper differentiation in the adult Drosophila midgut.
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