期刊
AGING CELL
卷 13, 期 6, 页码 1038-1048出版社
WILEY
DOI: 10.1111/acel.12266
关键词
cellular senescence; fibroblast; methionine; mitochondria; oxidative stress
资金
- Austrian Science Foundation (FWF) [NFN S93, SFB LIPOTOX P23490, P24381, W1226]
- Deutsche Forschungsgemeinschaft (DFG)
- Austrian Science Fund (FWF) [P 23490] Funding Source: researchfish
- Austrian Science Fund (FWF) [P24381, P23490, W1226] Funding Source: Austrian Science Fund (FWF)
Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex IV and diminished the accumulation of reactive oxygen species. Lifespan extension was accompanied by a significant decrease in the levels of subunits of mitochondrial complex IV, but also complex I, which was due to a decreased translation rate of several mtDNA-encoded subunits. Together, these findings indicate that MetR slows down aging in human cells by modulating mitochondrial protein synthesis and respiratory chain assembly.
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