期刊
AGING CELL
卷 13, 期 4, 页码 769-771出版社
WILEY-BLACKWELL
DOI: 10.1111/acel.12213
关键词
IGF-1; insulin-like growth factor 1; mortality; longevity; human; cancer
资金
- NIA [R00AG037574, 1P01AG034906, R01AG046949, 1R01AG042188, P30AG038072]
- NIH [R37AG18381]
- Einstein Glenn Center
- Paul Glenn Foundation
- AFAR
- CTSA [KL2TR000088]
Attenuated growth hormone and insulin-like growth factor-1 (GH/IGF-1) signaling is associated with extended lifespan in several animal models. However, the effect of diminished GH/IGF-1 activity on survival in humans has not been confirmed. We tested the hypothesis that IGF-1 levels in nonagenarians (n = 184), measured at study enrollment, predict the duration of their incremental survival. In the Kaplan-Meier analysis, females with IGF-1 levels below the median (<= 96 ng mL(-1)) had significantly longer survival compared with females with levels above the median, P < 0.01. However, this survival advantage was not observed in males (P = 0.83). On the other hand, in both males and females with a history of cancer, lower IGF-1 levels predicted longer survival (P < 0.01). IGF-1 level remained a significant predictor of survival duration in linear regression models after multivariable adjustment in females (P = 0.01) and individuals with a history of cancer (P < 0.01). We show for the first time that low IGF-1 levels predict life expectancy in exceptionally long-lived individuals.
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