期刊
AGING CELL
卷 11, 期 2, 页码 360-362出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1474-9726.2011.00778.x
关键词
Alzheimer's disease; DNA damage; Drosophila
资金
- Medical Research Council [G0902418] Funding Source: Medline
- Medical Research Council [G0902418] Funding Source: researchfish
- MRC [G0902418] Funding Source: UKRI
ATM and p53, effectors of the DNA damage checkpoint, are generally considered pro-apoptotic in neurons. We show that DNA damage and checkpoint activation occurs in postmitotic neurons in animal models of tauopathy, neurodegenerative disorders that include Alzheimers disease. Surprisingly, checkpoint attenuation potently increases neurodegeneration through aberrant cell cycle re-entry of postmitotic neurons. These data suggest an unexpected neuroprotective role for the DNA damage checkpoint in tauopathies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据