期刊
AGING CELL
卷 10, 期 5, 页码 879-884出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1474-9726.2011.00733.x
关键词
bile acid; nuclear receptor; endocrine signaling; hormone; development; aging
资金
- NIA [RO1AG027498]
- Max Planck Society
- Howard Hughes Medical Foundation, NIH [U19DK62434]
- Welch Foundation
- Natural Sciences and Engineering Research Council of Canada [356873-08]
- Canadian Institutes of Health Research [MOP-89361, 97904]
- Canada Foundation for Innovation
Bile acids are cholesterol-derived signaling molecules that regulate mammalian metabolism through sterol-sensing nuclear receptor transcription factors. In C. elegans, bile acid-like steroids called dafachronic acids (DAs) control developmental timing and longevity by activating the nuclear receptor DAF-12. However, little is known about the biosynthesis of these molecules. Here, we show that the DAF-36/Rieske oxygenase works at the first committed step, converting cholesterol to 7-dehydrocholesterol. Its elucidation as a cholesterol 7-desaturase provides crucial biochemical evidence that such oxygenases are key steroidogenic enzymes. By controlling DA production, DAF-36 regulates DAF-12 activities for reproductive development and longevity and may illuminate related pathways in metazoans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据