期刊
AGING CELL
卷 9, 期 1, 页码 100-103出版社
WILEY
DOI: 10.1111/j.1474-9726.2009.00537.x
关键词
dietary restriction; Drosophila; electron transport chain; mitochondria
资金
- NIA NIH HHS [P30-AG028748, P30 AG028748-01, P30 AG028748] Funding Source: Medline
P>Studies in a broad spectrum of model organisms have reported that dietary restriction (DR) is associated with an increase in mitochondrial electron transport chain (ETC) function. However, the question of whether ETC function is required for DR-mediated longevity remains controversial. Here, we report that genetic and pharmacological interventions that target mitochondrial complex V affect Drosophila lifespan in a nutrient-dependent manner. These findings support a requirement for mitochondrial complex V in DR-mediated longevity in flies.
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