期刊
AGING CELL
卷 8, 期 5, 页码 604-606出版社
WILEY
DOI: 10.1111/j.1474-9726.2009.00503.x
关键词
calorie restriction; longevity; mass spectrometry; metabolism; mitochondria; sirtuins
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM007753] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [K08AG022325] Funding Source: NIH RePORTER
- Howard Hughes Medical Institute Funding Source: Medline
- NIA NIH HHS [AG022325, K08 AG022325, K08 AG022325-06] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007753] Funding Source: Medline
P>Calorie restriction (CR) increases lifespan in organisms ranging from budding yeast through mammals. Mitochondrial adaptation represents a key component of the response to CR. Molecular mechanisms underlying this adaptation are largely unknown. Here we show that lysine acetylation of mitochondrial proteins is altered during CR in a tissue-specific fashion. Via large-scale mass spectrometry screening, we identify 72 candidate proteins involved in a variety of metabolic pathways with altered acetylation during CR. Mitochondrial acetylation changes may play an important role in the pro-longevity CR response.
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