期刊
AGING CELL
卷 8, 期 1, 页码 73-75出版社
WILEY
DOI: 10.1111/j.1474-9726.2008.00449.x
关键词
aging; antioxidant enzymes; transgenic and knockout mice
资金
- NIA NIH HHS [R37 AG026557, P01-AG-19316, P01 AG019316, R37-AG026557, P30 AG013319, 1P30-AG-13319] Funding Source: Medline
We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.
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