期刊
AGING CELL
卷 7, 期 3, 页码 394-404出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1474-9726.2008.00385.x
关键词
Caenorhabditis elegans; dietary restriction; hsf-1; longevity; proteotoxicitys
资金
- NIA NIH HHS [T32 AG000057, P50 AG005136, T32 AG000057-32, P50 AG005136-25, P30 AG013280, P30 AG013280-14, P01 AG001751] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [P30AG013280, P50AG005136, T32AG000057] Funding Source: NIH RePORTER
Dietary restriction increases lifespan and slows the onset of age-associated disease in organisms from yeast to mammals. In humans, several age-related diseases are associated with aberrant protein folding or aggregation, including neurodegenerative disorders such as Alzheimer's, Parkinson's, and Huntington's diseases. We report here that dietary restriction dramatically suppresses age-associated paralysis in three nematode models of proteotoxicity. Similar to its longevity-enhancing properties, dietary restriction protects against proteotoxicity by a mechanism distinct from reduced insulin/IGF-1-like signaling. Instead, the heat shock transcription factor, hsf-1, is required for enhanced thermotolerance, suppression of proteotoxicity, and lifespan extension by dietary restriction. These findings demonstrate that dietary restriction confers a general protective effect against proteotoxicity and promotes longevity by a mechanism involving hsf-1.
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