期刊
CLINICAL LYMPHOMA & MYELOMA
卷 9, 期 -, 页码 S272-S279出版社
CIG MEDIA GROUP, LP
DOI: 10.3816/CLM.2009.s.023
关键词
Farnesyltransferase inhibitors; Histone deacetylases; Kinase inhibitors; Omacetaxine; T3151 mutations
类别
Chronic myeloid leukemia (CML) is characterized at the molecular level by the presence of the Philadelphia chromosome (Ph) and the resultant oncogenic signaling by the BCR-ABL fusion protein. The treatment and outlook for CML were revolutionized by the introduction of imatinib, but resistance is a substantial barrier to successful treatment in many patients. Introduction of the second-generation tyrosine kinase inhibitors (TKI) dasatinib and nilotinib has provided effective therapeutic options for many patients with resistance to front-line imatinib. However, the T3151 mutation remains a significant clinical issue because it is insensitive to all currently available agents. A number of new agents are in development and many hold the promise of activity in T3151-mutated disease. Successful treatment of patients with disease harboring T3151 might lie in the effective combination or sequencing of these new agents with existing TKI therapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据