期刊
AGEING RESEARCH REVIEWS
卷 15, 期 -, 页码 6-15出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2013.12.007
关键词
Alzheimer's disease; lnflammasome; Inflammation; Astrocytes; Micrioglia; Interleukins
资金
- National Institute of Health [R01GM079688, R01GM089866]
- National Science Foundation [CBET 0941055]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [941055] Funding Source: National Science Foundation
Alzheimer's disease (AD) is a chronic, progressive and irreversible neurodegenerative disease with clinical characteristics of memory loss, dementia and cognitive impairment. Although the pathophysiologic mechanism is not fully understood, inflammation has been shown to play a critical role in the pathogenesis of AD. Inflammation in the central nervous system (CNS) is characterized by the activation of glial cells and release of proinflammatory cytokines and chemokines. Accumulating evidence demonstrates that inflammasomes, which cleave precursors of interleukin-1 beta (IL-1 beta) and IL-18 to generate their active forms, play an important role in the inflammatory response in the CNS and in AD pathogenesis. Therefore, modulating inflammasome complex assembly and activation could be a potential strategy for suppressing inflammation in the CNS. This review aims to provide insight into the role of inflammasomes in the CNS, with respect to the pathogenesis of AD, and may provide possible clues for devising novel therapeutic strategies. (C) 2014 Elsevier B.V. All rights reserved.
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