期刊
AGEING RESEARCH REVIEWS
卷 18, 期 -, 页码 1-15出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2014.07.001
关键词
Aging; Senescence; Mitochondria; mtDNA; ROS; Molecular mechanisms
资金
- Centro Cardiologico Monzino-IRCCS [RC2012-2015]
Aging is characterized by a progressive decline in organism functions due to the impairment of all organs. The deterioration of both proliferative tissues in liver, skin and the vascular system, as well as of largely post-mitotic organs, such as the heart and brain could be attributed at least in part to cell senescence. In this review we examine the role of mitochondrial dysfunction and mtDNA mutations in cell aging and senescence. Specifically, we address how p53 and telomerase reverse transcriptase (TERT) activity switch their roles from cytoprotective to detrimental and also examine the role of microRNAs in cell aging. The proposed role of Reactive Oxygen Species (ROS), both as mutating agents and as signalling molecules, underlying these processes is also described. (C) 2014 Elsevier B.V. All rights reserved.
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