期刊
AGEING RESEARCH REVIEWS
卷 12, 期 1, 页码 276-281出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2012.07.002
关键词
CKIP-1; PH domain; Localization; Interacting protein; Bone formation; Osteoporosis
资金
- National Basic Research Programs [2012CB518103, 2012CB910304, 2011CB910602]
- National Natural Science Foundations of China [31100554, 31125010, 30830029]
The PH domain-containing casein kinase 2 interacting protein-1 (CKIP-1, also known as PLEKHO1) acts as a scaffold protein mediating interactions with multiple proteins, including CK2 alpha, CP alpha, AP-1/c-Jun, Akt, ATM, IFP35/Nmi and Smurf1. CKIP-1 functions through different ways, such as plasma membrane recruitment, transcriptional activity modulation and posttranscriptional modification regulation. Moreover, the subcellular localization of CKIP-1 is determined by several key amino acids in a cell type dependent style, and the nucleus/plasma membrane shuttle of CKIP-1 is regulated by different cell stresses. As an adaptor protein, CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation. Strikingly, CKIP-1 has been recently demonstrated to be a promising target for treatment of osteoporosis in rat models. In addition, more evidences suggest that CKIP-1 might also function as a potential tumor suppressor. (c) 2012 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据