期刊
AGE AND AGEING
卷 43, 期 2, 页码 271-275出版社
OXFORD UNIV PRESS
DOI: 10.1093/ageing/aft210
关键词
lutein; zeaxanthin; cognition; macular pigment; ageing; older people
资金
- NIH [K23 EY000409, N01 AG62101, N01 AG62103, N01 AG62106]
- International Retinal Research Foundation
- Research to Prevent Blindness
- American Health Assistance Foundation
- DSM
Background: the xanthophylls lutein (L) and zeaxanthin (Z) exist in relatively high concentration in multiple central nervous tissues (e. g. cortex and neural retina). L + Z in macula (i.e. macular pigment, MP) are thought to serve multiple functions, including protection and improvement of visual performance. Also, L + Z in the macula are related to L + Z in the cortex. Objective: to determine whether macular pigment optical density (MPOD, L + Z in the macula) is related to cognitive function in older adults. Methods: participants were older adults (n = 108, 77.6 +/- 2.7 years) sampled from the age-related maculopathy ancillary study of the Health Aging and Body Composition Study (Memphis, TN, USA). Serum carotenoids were measured using high performance liquid chromatography. MPOD was assessed using heterochromatic flicker photometry. Eight cognitive tests designed to evaluate several cognitive domains including memory and processing speed were administered. Partial correlation coefficients were computed to determine whether cognitive measures were related to serum L + Z and MPOD. Results: MPOD levels were significantly associated with better global cognition, verbal learning and fluency, recall, processing speed and perceptual speed, whereas serum L + Z was significantly related to only verbal fluency. Conclusion: MPOD is related to cognitive function in older people. Its role as a potential biomarker of cognitive function deserves further study.
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