期刊
AGE AND AGEING
卷 38, 期 5, 页码 509-514出版社
OXFORD UNIV PRESS
DOI: 10.1093/ageing/afp093
关键词
Elderly; cognition; gait speed; ageing; significant cognitive decline
资金
- Italian Ministry of Health [ICS 110.1\RS97.71]
- National Institute on Aging [N01AG-916413, N01-AG-821336, N01-AG-5-0002]
- NIA [R01 AG027012]
- Intramural Research Program
- National Institute on Aging
- NIH
Design: prospective study. Setting: population-based sample of community-dwelling older persons. Participants: 660 older participants (age >= 65 years). Measurements: usual gait speed, fastest gait speed, gait speed during 'walking-while-talking', depression, comorbidities, education, smoking and demographics were assessed at baseline. Cognition was evaluated at baseline and follow-up. A decline in MMSE score by >= 3 points was considered as significant cognitive decline (SCD). Results: adjusting for confounders, only fast speed was associated with cognitive performance at 3-year follow-up. One hundred thirty-five participants had SCD over 3 years. Participants in the lowest quartile of usual speed or walking-while-talking speed were more likely to develop SCD. Conversely, participants in the third and fourth quartiles of fast speed were more likely to develop SCD. J-test showed that the model including fast speed quartiles as a regressor was significantly more predictive of SCD than the models with usual speed or walking-while-talking speed quartiles. Conclusion: measuring fast gait speed in older persons may assist in identifying those at high risk of cognitive decline.
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