期刊
AGE AND AGEING
卷 39, 期 1, 页码 74-80出版社
OXFORD UNIV PRESS
DOI: 10.1093/ageing/afp194
关键词
HDL cholesterol; physical function; inflammation; older persons; elderly
资金
- Italian Ministry of Health [SS9.4.2]
- University of Florida Institute on Aging
- NIH [1P30AG028740]
- National Institutes of Health-National Institute on Aging [1R01AG026556- 01A2]
- NATIONAL INSTITUTE ON AGING [R01AG026556, P30AG028740] Funding Source: NIH RePORTER
Objective: the aim of the study is to investigate the possible interaction of HDL-C on inflammation and physical function. Design: cross-sectional study. Setting: town of Tuscania (Italy). Subjects: all the 329 community-dwelling older persons aged >= 75 years (mean age 79.8 +/- 5.2 years, women 56.2%). Methods: HDL-C, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and interleukin-6 (IL-6) were measured. Activities of daily living (ADL), instrumental ADL (IADL) and 4-m walking speed were assessed. Linear regression models were performed. Results: given the multiple significant interactions, models were stratified according to HDL-C concentrations. In participants with normal HDL-C concentrations, only IL-6 showed a significant association with IADL (beta = -0.439, SE = 0.176, P = 0.01). In participants with low HDL-C concentrations, all three inflammatory biomarkers were significantly associated with 4-m walking speed and IADL. IL-6 was also significantly associated with ADL (beta = -0.755, SE = 0.259, P = 0.006), whereas borderline significances were reported for CRP and ESR. Conclusions: the association between inflammation and physical function is particularly enhanced in elders with low HDL-C concentrations. Though HDL-C may merely act as a wellbeing index, HDL-C concentrations should be considered in studies evaluating inflammation and physical function.
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