期刊
AGE
卷 36, 期 3, 页码 1033-1040出版社
SPRINGER
DOI: 10.1007/s11357-014-9618-3
关键词
Aging; Wnt pathway; Cellular senescence
资金
- NIH/NIA grants [R37 AG016694, R01 AG035328]
- NRSA individual predoctoral MD/PhD fellowship from the NIH/NIA [F30 AG035592]
- Glenn Award for Research on the Biological Mechanisms of Aging from the Glenn Foundation for Medical Research
- Biotechnology and Biological Sciences Research Council [BB/H021019/1] Funding Source: researchfish
- BBSRC [BB/H021019/1] Funding Source: UKRI
The Wnt signaling pathway is involved in the regulation of tissue patterning and organ development during embryogenesis and continues to contribute to the maintenance of tissue homeostasis in adulthood. Recently, Wnt signaling has also been implicated in the establishment and progression of replicative cellular senescence. Given the known roles of tissue homeostasis and cellular senescence in aging, we sought to determine whether Wnt signaling changes with age. We examined the expression of 84 Wnt pathway-related genes in the liver, lung, skeletal muscle, and brain tissue from young and old mice. Expression changes were compared with those seen in cellular senescence, and transcription factors that might mediate these changes were predicted bioinformatically. In aggregate, our data are indicative of a general decrease in Wnt signaling with age, especially in the lung and brain. Furthermore, the set of genes that are differentially expressed with age is distinct from the genes differentially expressed in cellular senescence. The transcription factors predicted to regulate these changes, Nf-kappa B, Myb, Nkx2-1, Nr5a2, and Ep300, are known to regulate inflammation, differentiation, lipid metabolism, and chromatin remodeling, all of which have previously been implicated in aging. Although our study does not address whether altered Wnt signaling is a cause or an effect of aging, the presence of a relationship between the two provides a starting point for further investigation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据