期刊
AGE
卷 35, 期 6, 页码 2255-2271出版社
SPRINGER
DOI: 10.1007/s11357-013-9521-3
关键词
Aging; Senescence; Copper; Metals; p38(MAPK); Oxidative stress; Human fibroblasts
资金
- Fonds de la Recherche dans l'industrie et l'agriculture (FRIA), Belgium
- Direction Generale Operationnelle de l'Economie, de l'Emploi et de la Recherche (DGO6) of the Public Service of Wallonia (SPW) [516252]
- European Commission [FP6-518230, INFRASTRUCTURE-2010-1-262163]
In the present work, we indicate that copper is involved in the senescence of human diploid fibroblasts and we describe mechanisms to explain it. Using different techniques, we show for the first time an accumulation of copper in cells during replicative senescence. This accumulation seems to be co-localized with lipofuscin. Second, we observed that an incubation of cells with copper sulfate induced oxidative stress, antioxidant response and premature senescence. Antioxidant molecules reduced the appearance of premature senescence. Third, we found that Nrf2 transcription factor was activated and regulated the expression of genes involved in antioxidant response while p38(MAPK) regulated the appearance of premature senescence.
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