期刊
AGE
卷 31, 期 4, 页码 327-341出版社
SPRINGER
DOI: 10.1007/s11357-009-9104-5
关键词
Dietary restriction; Sirt1; Resveratrol; Epigenetics; DNA methylation; Histone acetylation
资金
- BBSRC [BB/E007457/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [GR/T26580/01] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/E007457/1] Funding Source: Medline
Dietary restriction (DR) increases lifespan in a range of evolutionarily distinct species. The polyphenol resveratrol may be a dietary mimetic of some effects of DR. The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing. We propose the novel hypothesis that effects of DR relevant to lifespan extension include maintenance of DNA methylation patterns through Sirt1-mediated epigenetic effects, and proffer the view that dietary components, including resveratrol, may mimic these actions.
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