期刊
NATURE REVIEWS CANCER
卷 9, 期 11, 页码 773-784出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2736
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- Smurfit Institute of Genetics
- Adelaide Meath Hospital
- National Children's Hospita
- Trinity College Dublin
- Danish National Research Foundation
- Danish Cancer Society
- Novo Nordisk Foundation
- Danish Medical Research Council
- Danish Natural Science Research Council
- Lundbeck Foundation
- Association for International Cancer Research
- Excellence Programme of the University of Copenhagen
The Polycomb group (PcG) proteins are transcriptional repressors that regulate lineage choices during development and differentiation. Recent studies have advanced our understanding of how the PcG proteins regulate cell fate decisions and how their deregulation potentially contributes to cancer. In this Review we discuss the emerging roles of long non-coding RNAs (ncRNAs) and a subset of transcription factors, which we call cell fate transcription factors, in the regulation of PcG association with target genes. We also speculate about how their deregulation contributes to tumorigenesis.
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