期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 45, 期 9-10, 页码 595-603出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2015.02.013
关键词
Sarcocystis neurona; Marine mammal; Protozoal disease; Coccidia; Parasite; Genotype; SnSAG; Encephalitis
类别
资金
- National Institutes of Health (NIH)
- National Institute of Allergy and Infectious Diseases (NIAID), US
- John H. Prescott Marine Mammal Rescue Assistance Grant Program, USA
- NOAA Prescott Marine Mammal Rescue Grants, USA
- Washington Department of Fish and Wildlife, USA
- Cascadia Research Collective, USA
- Animal Health Center, British Columbia Ministry of Agriculture, Canada
Sarcocystis neurona is an important cause of protozoal encephalitis among marine mammals in the northeastern Pacific Ocean. To characterise the genetic type of S. neurona in this region, samples from 227 stranded marine mammals, most with clinical or pathological evidence of protozoal disease, were tested for the presence of coccidian parasites using a nested PCR assay. The frequency of S. neurona infection was 60% (1361227) among pinnipeds and cetaceans, including seven marine mammal species not previously known to be susceptible to infection by this parasite. Eight S. neurona fetal infections identified this coccidian parasite as capable of being transmitted transplacentally. Thirty-sevens. neurona-positive samples were multilocus sequence genotyped using three genetic markers: SnSAG1-5-6, SnSAG3 and SnSAG4. A novel genotype, referred to as Type XIII within the S. neurona population genetic structure, has emerged recently in the northeastern Pacific Ocean and is significantly associated with an increased severity of protozoal encephalitis and mortality among multiple stranded marine mammal species. Published by Elsevier Ltd. on behalf of Australian Society for Parasitology Inc.
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