期刊
INTERNATIONAL JOURNAL FOR PARASITOLOGY
卷 45, 期 4, 页码 237-242出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2014.11.003
关键词
Genetic resistance; Horse; Nematode; Heritability; Repeatability
类别
资金
- French Institute for Horse and Horse Riding (IFCE)
- Animal Health Carnot Institute program (ICSA)
Equine internal parasites, mostly cyathostomins, affect both horse welfare and performance. The appearance of anthelmintic-resistant parasites creates a pressing need for optimising drenching schemes. This optimization may be achieved by identifying genetic markers associated with host susceptibility to infection and then to drench carriers of these markers. The aim of our study was to characterise the genetics of horse resistance to strongyle infection by estimating heritability of this trait in an Arabian pure blood population. A population of 789 Arabian pure blood horses from the Michalow stud farm, Poland were measured for strongyle egg excretion twice a year, over 8 years. Low repeatability values were found for faecal egg counts. Our analyses showed that less than 10% of the observed variation for strongyle faecal egg counts in this population had a genetic origin. However, additional analyses highlighted an age-dependent increase in heritability which was 0.04 (+/- 0.02) in young horses (up to 3 years of age) but 0.21 (+/- 0.04) in older ones. These results suggest that a significant part of the inter-individual variation has a genetic origin. This paves the way to a genomic dissection of horse-nematode interactions which might provide predictive markers of susceptibility, allowing individualised drenching schemes. (C) 2015 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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