期刊
AEROSOL SCIENCE AND TECHNOLOGY
卷 43, 期 10, 页码 970-977出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/02786820903082029
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- TSE Systems, Inc., Chesterfield, MO 63005, USA
The use of respiratory tract dosimetry predictions to estimate the desired aerosol exposure concentration required for a specific target deposited dose in animal inhalation studies has been hindered by: (1) a lack of species/strain specific quantitative respiratory tract anatomy; and (2) verification by comparison of calculated and experimentally measured deposited doses. Using recent literature on tracheobronchial and pulmonary respiratory tract anatomy, dosimetry predictions for the Balb/c mouse were compared with deposited doses for 0.5, 1.0, and 2.0 micrometer diameter aerosols in a newly available nose-only exposure system. Spatial and temporal aerosol port to port uniformity of this nose-only exposure system was within +/- 10% of the mean. Dosimetry predictions were in agreement with the measured mean deposited doses for the aerosols tested.
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