期刊
NATURE REVIEWS IMMUNOLOGY
卷 9, 期 11, 页码 811-816出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri2654
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资金
- US National Institute of Health
- Juvenile Diabetes Research Foundation
- University of California
- San Francisco Diabetes Center
- National Health and Medical Research Council of Australia.
In 1986, Robert Coffman and Timothy Mossman first described the division of CD4(+) T cells into functional subsets, termed T helper 1 (T(H)1) and T(H)2, based on cytokine production, and in doing so unwittingly opened a Pandora's box of complexity and controversy. Although the mechanisms that regulate T(H)1 and T(H)2 cells are now well known, recent descriptions of other CD4(+) T cell subsets-such as regulatory T cells, T follicular helper cells, T(H)17, T(H)22 and most recently T(H)9 and T(H)22 cells-have questioned how we think of T cell subsets and what commitment to a functional T cell subset means. Here, Nature Reviews Immunology asks four leaders in the field their thoughts on the functional plasticity of T cell subsets.
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