期刊
ADVANCES IN THERAPY
卷 29, 期 7, 页码 635-644出版社
SPRINGER
DOI: 10.1007/s12325-012-0032-x
关键词
Diabetes mellitus; Glucose metabolism; High-dose telmisartan; High-molecular-weight adiponectin; Insulin resistance; Lipid profile
资金
- Ministry of Health, Labor, and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- University of Occupational and Environmental Health, Japan
- UOEH Grant for Advanced Research
- Mitsubishi-Tanabe Pharma Corporation
- Abbott Japan Co., Ltd.
- Eisai Co., Ltd.
- Chugai Pharmaceutical Co., Ltd.
- Janssen Pharmaceutical K.K.
- Santen Pharmaceutical Co., Ltd.
- Pfizer Japan Inc.
- Astellas Pharma Inc.
- Daiichi-Sankyo Co., Ltd.
- GlaxoSmithKline K.K.
- Astra-Zeneca
- Otsuka Pharmaceutical Co., Ltd.
- Actelion Pharmaceuticals Japan Ltd.
- Eli Lilly Japan K.K.
- Nippon Kayaku Co., Ltd.
- UCB Japan Co., Ltd.
- Quintiles Transnational Japan Co. Ltd.
- Ono Pharmaceutical Co., Ltd.
- Novartis Pharma K.K.
- Bristol-Myers Squibb
- MSD K.K.
The clinical dose of telmisartan necessary for activation of peroxisome proliferator-activated receptor gamma (PPAR-gamma) has not been established. The authors investigated the effect of high-dose telmisartan on serum levels of the high-molecular-weight (HMW) adiponectin in patients with diabetes and hypertension. In this open-label, prospective, randomized study, patients with type 2 diabetes and hypertension with poor control of blood pressure by 40 mg/day telmisartan were randomly assigned into the telmisartan 80 mg/day (Tel80) group (dose increase from 40 to 80 mg/day) or the telmisartan 40 mg + amlodipine 5 mg (Tel40 + Aml5) group. Serum levels of HMW adiponectin and parameters of glucose and lipid metabolism were measured at baseline and end of 3-months of treatment. Although the antihypertensive effects of the two doses of telmisartan were similar, a significant increase in HMW adiponectin levels was noted only in the Tel80 group. The increase was evident particularly in a group of patients whose HMW adiponectin levels were less than 4.0 mu g/dL. A significant improvement in homeostasis model assessment of insulin resistance (HOMA-IR), a measure of insulin resistance, was also observed in the Tel80 group only. In diabetic patients with hypertension, high-dose telmisartan increased HMW adiponectin levels and improved insulin resistance through activation of PPAR-gamma.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据