期刊
ADVANCES IN SPACE RESEARCH
卷 46, 期 6, 页码 687-700出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.asr.2010.04.012
关键词
High magnetic gradient environment; Diamagnetic levitation; Simulated weightlessness; Cytoskeleton; Osteoblast
类别
资金
- National Natural Science Foundation of China [30970706]
- National High-Tech R&D Program (863) of China [2008AA12A218, 2008AA12A220]
- NPU Foundation for Fundamental Research
The effects of a high magnetic gradient environment (HMGE) on the cytoskeletal architecture and genes associated with the cytoskeleton in osteoblasts (MC3T3-EI and MG-63 cells) were investigated using confocal microscopy, real-time polymerase chain reaction (PCR) and atomic force microscopy (AFM). The findings showed that, under diamagnetic levitation conditions, the architecture and average height of the cytoskeleton and surface roughness in osteoblasts were dramatically altered. HMGE affects cytoskeleton arrangement and cytoskeleton-associated gene expression. (C) 2010 COSPAR. Published by Elsevier Ltd. All rights reserved.
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