期刊
EMERGING INFECTIOUS DISEASES
卷 15, 期 12, 页码 2013-2016出版社
CENTERS DISEASE CONTROL
DOI: 10.3201/eid1512.090194
关键词
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资金
- European Network of Excellence NeuroPrion [FOOD-CT-2004-506579]
- Scottish National Blood Transfusion Services
- Chief Scientist Office of the Scottish Government [CZB/4/357]
- Department of Health
- Scottish Government
- Biotechnology and Biological Sciences Research Council [BBS/E/D/05241340, BBS/E/D/05241338] Funding Source: researchfish
- Medical Research Council [G0600953, G0900580] Funding Source: researchfish
- BBSRC [BBS/E/D/05241340, BBS/E/D/05241338] Funding Source: UKRI
- MRC [G0900580, G0600953] Funding Source: UKRI
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies (TSEs), we investigated the ability of disease-associated prion proteins (PrP(d)) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrP(d) partly determines host susceptibility.
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