期刊
PSYCHIATRIC QUARTERLY
卷 80, 期 4, 页码 213-218出版社
SPRINGER
DOI: 10.1007/s11126-009-9108-4
关键词
Schizophrenia; Cannabis; Gene-environment interaction; COMT; Affective symptoms
类别
资金
- NCRR NIH HHS [KL2 RR024138-03, KL2 RR024138] Funding Source: Medline
- NIDA NIH HHS [R01 DA012853, R01-DA12853] Funding Source: Medline
Cannabis has been reported as a likely risk factor for the development of psychosis, and a gene x environment interaction with the catechol-O-methyltransferase (COMT) gene has been proposed. Moreover, COMT has been separately linked to affective symptoms in psychosis. Despite a high rate of cannabis abuse and affective symptoms in African Americans, no studies exploring a relationship between COMT and psychosis in this group have been reported. An existing database of psychotic patients with and without adolescent cannabis use/affective symptoms was examined, and chi-square analyses for independence were applied separately for both Caucasians and African-Americans to examine genotype associations with adolescent cannabis use and affective symptoms (past or present). The two subject groups did not differ with respect to the prevalence of adolescent cannabis abuse or presence of affective symptoms. Further study is needed, with non-psychotic controls and larger samples.
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