期刊
CLINICAL LYMPHOMA & MYELOMA
卷 9, 期 6, 页码 417-424出版社
CIG MEDIA GROUP, LP
DOI: 10.3816/CLM.2009.n.083
关键词
BCR-ABL; Imatinib intolerance; Imatinib resistance; Tyrosine kinase inhibitors
类别
资金
- NIHR Biomedical Research Centre
Imatinib is currently regarded as the best initial treatment for patients with chronic myeloid leukemia (CML). However, a significant proportion of patients who relapse, fail to respond, or develop intolerance might benefit from the use of second-generation tyrosine kinase inhibitors. In this review, we report the 2-year results in 8 clinical trials involving more than 2000 patients treated with dasatinib (phases I-III). Patients with CML who had failed to respond or were intolerant to imatinib were enrolled in a phase I trial. The positive results emanating from this study led to a series of 5 phase II trials known as START (SRC/ABL tyrosine kinase inhibition activity: research trials of dasatinib). In addition, 2 phase III dose-optimization trials have now been completed. These trials demonstrate that dasatinib offers clinical benefit to patients resistant or intolerant to imatinib, with a well-described and manageable adverse event profile.
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