期刊
JOURNAL OF ANXIETY DISORDERS
卷 23, 期 8, 页码 1064-1071出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.janxdis.2009.07.008
关键词
Generalized anxiety disorder; Pain; Duloxetine; Relapse prevention; Serotonin and norepinephrine reuptake inhibitor
Generalized anxiety disorder (GAD) is associated with painful physical symptoms (PPS). These post hoc analyses of previous trial data assessed PPS and their response to duloxetine treatment in GAD patients. Studies 1 and 2 (n = 840) were 9- to 10-week efficacy trials; study 3 (n = 887) was a relapse prevention trial comprising a 26-week open-label treatment phase and a 26-week double-blind, placebo-controlled treatment continuation phase. Mean baseline visual analog scale scores (VAS, 0-100; n = 1727) ranged from 26 to 37 for overall pain, headache, back pain, shoulder pain, interference with daily activities, and time in pain while awake. In studies I and 2, improvement on all VAS scores was greater in duloxetine-treated than in placebo-treated patients (p <= 0.01). In study 3, pain symptoms worsened in responders switched to placebo compared with those maintained on duloxetine (p <= 0.02). In conclusion, duloxetine was efficacious in the short- and long-term treatment of PPS, which are common in GAD patients. (C) 2009 Elsevier Ltd. All rights reserved.
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