期刊
ADVANCES IN COLLOID AND INTERFACE SCIENCE
卷 207, 期 -, 页码 155-163出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cis.2013.10.029
关键词
Lipids; Protein; Poly(NIPAM); Mesoporous silica nanopartides; Biomedical application
资金
- National Basic Research Program of China (973 Program) [2009CB930100, 2013CB932800]
- National Nature Science Foundation of China [21003027, 21273055]
In the past decade, mesoporous silica nanoparticles (MSNs) as nanocarriers have showed much potential in advanced nanomaterials due to their large surface area and pore volume. Especially, more and more MSNs based nanodevices have been designed as efficient drug delivery systems (DDSs) or biosensors. In this paper, lipid, protein and poly(NIPAM) coated MSNs are reviewed from the preparation, properties and their potential application. We also introduce the preparative methods including physical adsorption, covalent binding and self-assembly on the MSNs' surfaces. Furthermore, the interaction between the aimed cells and these molecular modified MSNs is discussed. We also demonstrate their typical applications, such as photodynamic therapy, bioimaging, controlled release and selective recognition in biomedical field. (C) 2013 Elsevier B.V. All rights reserved.
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