期刊
ADVANCES IN COLLOID AND INTERFACE SCIENCE
卷 208, 期 -, 页码 161-176出版社
ELSEVIER
DOI: 10.1016/j.cis.2014.03.002
关键词
Microfluidics; Hydrodynamic lift; Vesicles; Red blood cells; Lab on a chip; Cell sorting and separation
资金
- DFG via FR [2473/4-2]
- [SPP 1506]
Hydrodynamic lift forces acting on cells and particles in fluid flow receive ongoing attention from medicine, mathematics, physics and engineering. The early findings of Fahrus & Lindqvist on the viscosity change of blood with the diameter of capillaries motivated extensive studies both experimentally and theoretically to illuminate the underlying physics. We review this historical development that led to the discovery of the inertial and non-inertial lift forces and elucidate the origins of these forces that are still not entirely clear. Exploiting microfluidic techniques induced a tremendous amount of new insights especially into the more complex interactions between the flow field and deformable objects like vesicles or red blood cells. We trace the way from the investigation of single cell dynamics to the recent developments of microfluidic techniques for particle and cell sorting using hydrodynamic forces. Such continuous and label-free on-chip cell sorting devices promise to revolutionize medical analyses for personalized point-of-care diagnosis. We present the state-of-the-art of different hydrodynamic lift-based techniques and discuss their advantages and limitations. (C) 2014 Elsevier B.V. All rights reserved.
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