期刊
ACS APPLIED MATERIALS & INTERFACES
卷 7, 期 48, 页码 26400-26404出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b09820
关键词
electrospinning; bicomponent; control release; intra-abdominal infections; antibacterial activity
资金
- National Nature Science Foundation of China [51003110]
- Knowledge Innovation Program of the Chinese Academy of Sciences [KJCX2-YM-H19]
Implantation of sustained antibacterial system after abdominal surgery could effectively prevent complicated intra-abdominal infection. In this study, a simple blended electrospun membrane made of poly(D,L-lactic-co-glycolide) (PLGA)/poly(dioxanone) (PDO)/Ciprofloxacin hydrochloride (CiH) could easily result in approximately linear drug release profile and sustained antibacterial activity against both Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). The addition of PDO changed the stack structure of PLGA, which in turn influenced the fiber swelling and created drug diffusion channels. It could be a good candidate for reducing postoperative infection or be associated with other implant to resist biofilm formation.
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