期刊
ADVANCES IN CHRONIC KIDNEY DISEASE
卷 18, 期 2, 页码 105-112出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ackd.2010.12.002
关键词
Vascular calcification; Phosphate; Chronic kidney disease; Smooth muscle cell; Elastin degradation
资金
- NIH [R01 HL62329, R01 HL081785-01]
- Veteran's Administration
- NIH-NIDDK
Elevated serum phosphate has clinically been associated with vascular stiffness and cardiovascular mortality. Mechanistic studies over the past decade regarding local effects of phosphate on the vessel wall have provided insight into various pathways that culminate in vascular calcification. Smooth muscle cell phenotype change and apoptosis play prominent roles. The sodium phosphate cotransporter PiT-1 is required for the osteochondrogenic differentiation of smooth muscle cells in vitro. Less is known about phosphate-driven valve interstitial cell calcification and elastin degradation. In this article, we review the current knowledge about phosphate-induced changes in the vascular wall. (C) 2011 by the National Kidney Foundation, Inc. All rights reserved.
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